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KMID : 0378019720150050090
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New Medical Journal
1972 Volume.15 No. 5 p.90 ~ p.94
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Influence of Panax Ginseng upon Blood Corpuscles of Immature Rat
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정하영/Chung, Ha Yung
김학렬/Kim, Hak Ryul
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Abstract
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A study was planned to evaluate the effect of repeated administration of ginseng upon red and white blood cell counts, hemoglobin content and hematocrit of immature rats.
One hundred fourty immature male rats (body weight: 35-40 gm) were divided equally into the ginseng and the saline groups. Every day for 45 days, the ginseng group received subcutaneously 0.5 ml per 100 gm body weight of ginseng alcohol extract solution (4 mg of ginseng alcohol extract dissolved in 1 ml of normal saline), and the saline group received the same amount of normal saline. Two hours after drug adminitration on the 1st, 5th, 10th, 15th, 25th, 35th and 45th day after beginning of medication, 10 rats at a time of each group had their blood drawn out of the tail vein under anesthesia. Red and white blood cells were counted with hemocytometer, hemoglobin content was measured with hemometer, and hematocrit with a capillary tube for that purpose.
Following results were obtained:
1. In the saline group, red blood cell count, hemoglobin content and hematocrit value decreased progressively until 25th experimental day, after which they gradually recovered and regained their normal value on 35th experimental day. White blood cell count increased continuously through the experiment.
2. In the ginseng group, red blood cell count, hemoglobin content and hematocrit value decreased earlier, but then recovered also earlier and retained higher values than they did in the saline group. White blood cell count increased hand in hand with that of the saline group until 15th experimental day, but then the increment lagged behind that of the saline group.
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